Not as much as you may think...

When you design your site, focus on tonal value and contrast, this is more important than hues and shades because all monitors vary.  Try to use "Web Safe" colors.  This is a palette of colors that can be viewed even on 8-bit color screens.

When a display color is out of a computers range it will try to combine two to three colors in it's range to trhy and create the color causing the picture to look grainy.  This is called dithering.



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